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KMID : 0617319910010010150
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Journal of Pharmacetical Sceiences Ewha Womans University
1991 Volume.1 No. 1 p.150 ~ p.155
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Preparation and Dissolution Properties of Ftorafur-Gelatin Microcapsules
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Abstract
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Gelatin microcapsules containing Ftorafur, a hydrophilic anticancer agent, were prepared with congealable disperse-phase emulsification method. The preparation was based on dispersion of ftorafurgelatin solution with Tween #40 or #20 in liquid paraffin. A cationic surfactant, benzethonium chloride, was used to prevent the microcapsules from aggregation. In the case of microcapsules prepared with Tween #40 or Span #20, mean particle size decreased and narrow size distribution was observed. The intrinsic dissolution rate of ftorafur in microcapsules with 1% span #20 was 8.5 times lower than that of intact ftorafur.
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